Extracellular matrix motion and early morphogenesis
نویسندگان
چکیده
منابع مشابه
Bidirectional extracellular matrix signaling during tissue morphogenesis.
Normal tissue development and function are regulated by the interplay between cells and their surrounding extracellular matrix (ECM). The ECM provides biochemical and mechanical contextual information that is conveyed from the cell membrane through the cytoskeleton to the nucleus to direct cell phenotype. Cells, in turn, remodel the ECM and thereby sculpt their local microenvironment. Here we r...
متن کاملThe role of extracellular matrix in vascular branching morphogenesis
Angiogenesis requires the development of a hierarchically branched network of vessels, which undergoes radial expansion and anastomosis to form a close circuit. Branching is achieved by coordinated behavior of endothelial cells that organize into leading "tip" cells and trailing "stalk" cells. Such organization is under control of the Dll4-Notch signaling pathway, which sets a hierarchy in rece...
متن کاملPutative functions of extracellular matrix glycoproteins in secondary palate morphogenesis
Cleft palate is a common birth defect in humans. Elevation and fusion of paired palatal shelves are coordinated by growth and transcription factors, and mutations in these can cause malformations. Among the effector genes for growth factor signaling are extracellular matrix (ECM) glycoproteins. These provide substrates for cell adhesion (e.g., fibronectin, tenascins), but also regulate growth f...
متن کاملExtracellular matrix regulation of epithelial behaviour in morphogenesis
The substratum for many cell types is the extracellular matrix (ECM). However, the ECM is not only a physical supporting framework for the cells, but may be linked to the cells by molecules which are intimately associated with the plasma membrane. Changes in cell-ECM interactions modify cell shape, motility, and proliferation and, because the ECM distributes over many cells, can integrate these...
متن کاملExtracellular Matrix Dynamics in Early Development
The extracellular matrix (ECM) is an inherently dynamic structure during development. Large-scale tissue movements sweep the ECM to distant positions during early embryogenesis; furthermore, the previously assembled ECM filaments are extensively reused during later organogenesis. Thus, some organs, such as the heart, inherit previously assembled ECM filaments. This review focuses on the macro-a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development
سال: 2016
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.127886